Pain is the most common symptom of disease.Management depends on determining its cause, alleviating triggering and potentiating factors, and providing rapid relief whenever possible.
Organization of Pain Pathways
Pain-producing (nociceptive) sensory stimuli in skin and viscera activate peripheral nerve endings of primary afferent neurons, which synapse on secondorder neurons in cord or medulla.These second-order neurons form crossed ascending pathways that reach the thalamus and are projected to somatosensory cortex. Parallel ascending neurons connect with brainstem nuclei and ventrocaudal and medial thalamic nuclei.These parallel pathways project to the limbic system and underlie the emotional aspect of pain.
Pain transmission is regulated at the dorsal horn level by descending bulbospinal pathways that contain serotonin, norepinephrine, and several neuropeptides. Agents that modify pain perception may act to reduce tissue inflammation (NSAIDs, prostaglandin synthesis inhibitors), to interfere with pain transmission (narcotics), or to enhance descending modulation (narcotics and antidepressants). Anticonvulsants (gabapentin, carbamazepine) may be effective for aberrant pain sensations arising from peripheral nerve injury.
Evaluation
Pain may be of somatic (skin, joints, muscles), visceral, or neuropathic (injury to nerves, spinal cord pathways, or thalamus) origin. Characteristics of each are summarized in Table the following.
Neuropathic pain definitions: neuralgia: pain in the distribution of a single nerve, as in trigeminal neuralgia; dysesthesia: spontaneous, unpleasant, abnormal sensations; hyperalgesia and hyperesthesia: exaggerated responses to nociceptive or touch stimulus, respectively; allodynia: perception of light mechanical stimuli as painful, as when vibration evokes painful sensation.Reduced pain perception is called hypalgesia or, when absent, analgesia. Causalgia is continuous severe burning pain with indistinct boundaries and accompanying sympathetic nervous system dysfunction (sweating; vascular, skin, and hair changes—sympathetic dystrophy) that occurs after injury to a peripheral nerve.
Sensitization refers to a lowered threshold for activating primary nociceptors following repeated stimulation in damaged or inflamed tissues; inflammatory mediators play a role.Sensitization contributes to tenderness, soreness, and hyperalgesia (as in sunburn). Referred pain results from the convergence of sensory inputs from skin and viscera on single spinal neurons that transmit pain signals to the brain.Because of this convergence, input from deep structures is mislocalized to a region of skin innervated by the same spinal segment.
Treatment
Acute Somatic Pain If moderate, it can usually be treated effectively with nonnarcotic analgesics, e.g., aspirin, acetaminophen, and NSAIDs (Table 8-2).All inhibit cyclooxygenase (COX) and, except for acetaminophen, all have anti-inflammatory actions, especially at high dosages.For subacute musculoskeletal pain and arthritis, selective COX-2 inhibitors such as celecoxib are useful, especially if the pt is at risk for upper gastrointestinal ulceration or bleeding.Narcotic analgesics are usually required for relief of severe pain; the dose should be titrated to produce effective analgesia.
Chronic Pain
The problem is often difficult to diagnose, and pts may appear emotionally distraught.Psychological evaluation and behaviorally based treatment paradigms are frequently helpful, particularly in a multidisciplinary pain management center.
Several factors can cause, perpetuate, or exacerbate chronic pain: (1) painful disease for which there is no cure (e.g., arthritis, cancer, migraine headaches, diabetic neuropathy); (2) neural factors initiated by a bodily disease that persist after the disease has resolved (e.g., damaged sensory or sympathetic nerves); (3) psychological conditions. Pay special attention to the medical history and to depression.Major depression is common, treatable, and potentially fatal (suicide).
Treatment
After evaluation, an explicit treatment plan should be developed, including specific and realistic goals for therapy, e.g., getting a good night’s sleep, being able to go shopping, or returning to work.A multidisciplinary approach that utilizes medications, counseling, physical therapy, nerve blocks, and even surgery may be required to improve the pt’s quality of life.Some pts may require referral to a pain clinic; for others, pharmacologic management alone can provide significant help.The tricyclic antidepressants are useful in management of chronic pain from many causes, including headache, diabetic neuropathy, postherpetic neuralgia, atypical facial pain, chronic low back pain, and post-stroke pain.Anticonvulsants or antiarrhythmics benefit pts with neuropathic pain and little or no evidence of sympathetic dysfunction (e.g., diabetic neuropathy, trigeminal neuralgia).The combination of the anticonvulsant gabapentin and an antidepressant such as nortriptyline may be effective for chronic neuropathic pain.
The long-term use of opioids is accepted for pain due to malignant disease but is controversial for chronic pain of nonmalignant origin.When other approaches fail, long-acting opioid compounds such as levorphanol, methadone, sustained-release morphine, or transdermal fentanyl may be considered for these pts (Table 8-2).
 |
 |
Salam
Source: Manual of Medicine
Image: dicakila.wp.com
3 comments:
Avoiding Low Back Pain – And Hip Pain Treatment
http://aheartmedicine.com/avoiding-low-back-pain-and-hip-pain-treatment/
Hi, This is a good post, indeed a great job. You must have done good research for the work, i appreciate your efforts.. Looking for more updates from your side. Thanks
Pain Management Greeley CO
Here is a great herbal doctor who cured me of Hepatitis B. his name is Dr. Imoloa. I suffered Hepatitis B for 11 years, I was very weak with pains all over my body my stomach was swollen and I could hardly eat. And one day my brother came with a herbal medicine from doctor Imoloa and asked me to drink and I drank hence there was no hope, and behold after 2 week of taking the medicine, I started feeling relief, my swollen stomach started shrinking down and the pains was gone. I became normal after the completion of the medication, I went to the hospital and I was tested negative which means I’m cured. He can also cure the following diseases with his herbal medicine...lupus, hay fever, measles, dry cough, diabetics hepatitis A.B.C, mouth ulcer, mouth cancer, bile salt disease, fol ate deficinecy, diarrhoea, liver/kidney inflammatory, eye cancer, skin cancer disease, malaria, chronic kidney disease, food poisoning, parkinson disease, bowel cancer, bone cancer, brain tumours, asthma, arthritis, epilepsy, cystic fibrosis, lyme disease, muscle aches, fatigue, alzhemer's disease, acute myeloid leukaemia, acute pancreatitis, chronic inflammatory joint disease, Addison's disease back acne, breast cancer, allergic bronchitis, Celia disease, bulimia, congenital heart disease, cirrhosis, constipation, fungal nail infection, fabromyalgia, (love spell) and many more. he is a great herbalist man. Contact him on email; drimolaherbalmademedicine@gmail.com. You can also reach him on whatssap- +2347081986098.
Post a Comment